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Department of Internal Medicine

Anne A. Knowlton, M.D.

Clinical/Research Interests

Anne A. Knowlton specializes in cardiology, with particular interests in atrial fibrillation and heart failure. She graduated from Harvard University magna cum laude with a degree in biology. After earning her medical degree from Yale University and doing her internship and residency training at Boston City Hospital, Knowlton completed a cardiology fellowship at Boston University Medical Center. She was honored with a National Research Award as a postdoctoral fellow at the Cardiovascular Institute at Boston University School of Medicine from 1984 to 1986. Knowlton has research interests in heat shock protein, apoptosis, heart failure and estrogen. She has written numerous papers and several book chapters on topics related to cardiovascular medicine and serves on the editorial board of the Journal of Molecular and Cellular Cardiology.

Title:

 Associate Professor

Specialty:

 Cardiovascular Medicine

Education:

 Yale University School of Medicine
New Haven, Connecticut
M.D. 1979

Harvard University
Boston, Massachusetts
A.B. 1974

Internships:

 Boston City Hospital
Boston, Massachusetts
1979
Medicine

Residency:

 Boston City Hospital
Boston, Massachusetts
1980-82
Medicine

Fellowships:

 Boston University Medical Center
Boston, Massachusetts
1982-84
Cardiology

Board Certifications:

 American Board of Internal Medicine, Cardiology, 1987
American Board of Internal Medicine, 1984

Professional Memberships:

 American Federation for Medical Research
American Heart Association
American Physiological Society
American Society of Microbiology
Council on Basic Science, AHA
Fellow, American College of Cardiology
International Society for Heart Research

Select Recent Publications:

Trial, J, R.D.Rossen, and A.A.Knowlton.(2004) Inflammation and ischemia: Macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. Exp. Biol. Med. 229:538-545.

Hamilton, K, S. Gupta and A.A.Knowlton.(2004) Estrogen and Regulation of Heat Shock Protein Expression in Female Cardiomyocytes: Cross-talk with NF6B Signaling. J. Mol. Cell. Cardiol 36:579-586.

Voss, M, J. Stallone, M. Li, P. Knuefermann, A.A.Knowlton. (2003) Gender Differences in the Expression of Heat Shock Proteins: The Effect of Estrogen. Am. J. Physiol. 285:H687-H692.

Li,M, M.M.Ittmann, D.R.Rowley, A.A.Knowlton, Vaid, A.K., D.E. Epner. (2003) Glutathione S-transferase B is Up Regulated in the Stromal Compartment of Hormone Independent Prostate Cancer. Prostate 56:98-105.

Bozkurt, B,I. Agoston, and A.A. Knowlton. (2003) Complications of inappropriate use of spironolactone in heart failure: When an old medicine spirals out of new guidelines. J. Amer. Coll. Cardiol. 41:211-214.

Kirchhoff, S.R., S. Gupta, A.A. Knowlton. (2002) Cytosolic HSP60, apoptosis and myocardial injury. Circulation 105:2899-2904.

Wang, Y-H, A.A. Knowlton and S.C. Borkan HSP 72 Expression Enhances Survival in ATP Depleted Renal Epithelial Cells. (2002) Cell Stress and Chaperones 7:137-145.

Gupta,S. and A.A. Knowlton Cytosolic HSP60, Hypoxia, and Apoptosis. (2002) Circulation 106:2727-2733.

Knowlton, A.A. (2001) Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock. J. Mol. Cell. Cardiol.33:49-55.

Chang, J, A.A. Knowlton, J.S. Wasser (2001) Activation of the heat shock response: Relationship to energy metabolites. Am. J. Physiol. 280:H426-H433.