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Department of Internal Medicine

Nobuko Hagiwara

Clinical/Research Interests

Nobuko Hagiwara has expertise in the field of molecular genetics. She completed postdoctoral training at the University of Iowa in biological sciences and the University of California, Irvine, in anatomy and neurobiology. She also was a postdoctoral fellow at the Fox Chase Cancer Center Institute for Cancer Research in Philadelphia, Penn., and the University of Arizona College of Medicine in Tucson, where she focused on pediatrics. Hagiwara has research interests in the molecular genetics of cardiac and central nervous system development. She intends to investigate the mechanisms underlying congestive heart failure, cardiomyopathies and sudden death.

Title:

 Assistant Professor

Specialty:

 Cardiovascular Medicine

Education:

 Ochanomizu Women's University
Tokyo
Japan
B.S. 1994

Professional Memberships:

 American Association for the Advancement of Science
Society for Neuroscience

Select Recent Publications:

Newton, J.M., Cohen-Barak, O., Hagiwara, N., Gardner J.M., Davisson, M.T., King, R.A., Brilliant M.H. Mutations in the human orthologue of the mouse underwhite (uw) gene underlie a new form of oculocutaneous albinism, OCA4. Am. J. Hum. Genet. 69:981-988, 2001.

Cohen-Barak, O., Hagiwara, N., Arlt, M.F., Horton, J.P., and Brilliant, M.H. Cloning, characterization and chromosome mapping of the human SOX6 gene. Gene 265: 157-164, 2001.

Hagiwara, N., Klewer, S.E., Samson, R.A., Erickson, D.T., Lyon, M.F., and Brilliant, M.H. Sox6 is a candidate gene for p100H myopathy, heart block and sudden neonatal death. Proc. Natl. Acad. Sci. USA 97: 4180-4185, 2000.

Gardner, J.M., Wildenberg, S.C., Keiper, N.M., Novak, E.K., Rusiniak, M.E., Swank, R.T., Puri, N., Finger, J.N., Hagiwara, N., Lehman, A.L., Gales, T.L., Bayer, M.E., King, R.A., and Brilliant, M.H. The mouse pale ear (ep) mutation is the homologue of human Hermansky-Pudlak Syndrome. Proc. Natl. Acad. Sci. USA 94: 9238-9243, 1997.

Homanics, G.E., DeLorey, T.M., Firestone, L.L., Quinlan, J.J., Handforth, A., Harrison, N.L., Krasowski, M.D., Rick, C.E., Korpi, E.R., Makela, R., Brilliant, M.H., Hagiwara, N., Ferguson, C., Snyder, K., and Olsen, R.W. Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc. Natl. Acad. Sci. USA 94 (8): 4143-4148, 1997.

In: Growth Factors as Drugs for Neurological and Sensory Disorders. Wiley, Chichester (Ciba Foundation Symposium 196) Calof, A. L., Hagiwara, N., Holcomb, J. D., Mumm, J. S., and Shou, J. Neurogenesis and cell death in the olfactory epithelium. J. Neurobiol. 30 (1): 67-81, 1996.

Calof, A. L., Holcomb, J. D., Mumm, J. S., Hagiwara, N., Tran, P., Smith, K.M., and Shelton, D.L. Factors affecting neuronal birth and death in mammalian olfactory epithelium, 1995.

Hagiwara, N. and Sueoka, N. Regulation of the rat S100ß gene: the role of the 2 kb 5'-upstream sequence in glial specific expression. J. Neurosci. Res. 42:603-612, 1995.

Kaneko, R., Hagiwara, N., Leader, K., and Sueoka, N. Glial-specific cAMP response of the glial fibrillary acidic protein gene in RT4 cell lines. Proc. Natl. Acad. Sci. USA 91:4529-4533, 1994.

Hagiwara, N., Imada, S., and Sueoka, N. Cell-type specific segregation of transcriptional expression of glial genes in the rat peripheral neurotumor RT4 cell lines. J. Neurosci. Res. 36: 646-656, 1993.