Clinical/Research Interests

Dr. Jialal specializes in cardiovascular pathology and clinical chemistry and toxicology. His research interests include cardiovascular pathology, lipoprotein metabolism, free-radical biology and mechanisms of antioxidant actions as they relate to atherosclerosis.

Dr. Jialal has published over 350 original papers and invited reviews in the areas of diabetes, atherosclerosis, lipid metabolism, nutrition and vascular biology. He has received numerous awards for his research, and has served on the editorial boards of numerous journals, including: American Journal of Clinical Nutrition, Journal of Molecular and Cellular Cardiology and Atherosclerosis. Currently, Dr. Jialal serves as section editor of the American Journal of Clinical Pathology for Clinical Chemistry and editor-in-chief of Metabolic Syndrome and Related Disorders. His major research interests are in the role of oxidative stress and inflammation in atherosclerosis, understanding the cellular dysfunction and the role of inflammation in metabolic syndrome, and understanding the pathobiology of diabetic vasculopathies. He also has a long-standing interest in hyperlipidemia and diabetes. His research has been funded over the years by the National Institutes of Health (NIH), the American Diabetes Association, the Juvenile Diabetes Research Foundation and the American Heart Association. He serves on the grant review panels of the American Diabetes Association and Juvenile Diabetes Research Foundation, as well as the National Institutes of Health, including the Mentored Clinical Scientist Development Award Grant Review Panel for the K-8 awards study section and other special-emphasis panels for the National Heart, Lung and Blood Institute.

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Select Recent Publications:

Devaraj S, Glaser N, Griffen S, Wang-Polagruto J, Miguelino E, Jialal I. Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. Diabetes, 55(3):774-779, 2006.

Venugopal S, Devaraj S, Jialal I. Macrophage-conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: Potential for paracrine/autocrine effects. Am J Pathol, 166(4):1265-1271, 2005.

Devaraj S, Venugopal S, Singh U, Jialal I. Hyperglycemia induces monocytic release of interleukin-6 via induction of PKC a and b. Diabetes, 54(1):85-91, 2005.

Devaraj S, Du Clos T, Jialal I. Binding and internalization of C-reactive protein by Fc gamma receptors on human aortic endothelial cells mediates biological effects. Arterioscler Thromb Vasc Biol, 25(7):1359-63, 2005.

Devaraj S, Xu D, Jialal I. C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: Implications for the metabolic syndrome and atherothrombosis. Circulation, 107(3):398-404, 2003.

Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation, 106(12):1439-1441, 2002.

Miller M, Jialal I. Effects of simvastatin in (40 mg and 80 mg) on highly sensitive C-reactive protein in patients with combined hyperlipidemia. Am J Cardiol, 89:468-469, 2002.

Hsu R, Marangon K, Devaraj S, Jialal I. Autoantibodies to oxidized low-density lipoprotein in patients with type 2 diabetes mellitus. Clin Chim Acta, 317:145-150, 2002.

Jialal I, Stein D, Balis D, Grundy SM, Adams-Huet B, Devaraj S. Effect of HMG-CoA reductase inhibitor therapy on highly sensitive C-reactive protein levels. Circulation, 103:1933-35, 2001.