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Department of Internal Medicine

Nipavan Chiamvimonvat, M.D.

Clinical/Research Interests

Nipavan Chiamvimonvat completed a two-year clinical cardiac arrhythmia fellowship at the University of Calgary and was also a research fellow at Johns Hopkins University from 1993 to 1997. Her clinical activities include attending for pacemaker and defibrillator clinics, coronary care unit service, and consult service. Chiamvimonvat's research goal is to understand the cellular and molecular mechanisms contributing to cardiac arrhythmias and sudden cardiac death in patients with cardiac hypertrophy and failure. She is working to develop a multidisciplinary research initiative in cardiovascular biology, which will include emphasis on fundamental mechanisms in cardiac arrhythmias and cardiac ion channelopathy.

Title:

 Associate Professor
Associate Chief for Research, Division of Cardiovascular Medicine

Specialty:

 Cardiovascular Medicine

Center/Program Affiliation:

 Heart Center

Education:

 University of Toronto
Toronto, Ontario
Canada
M.D. 1984

University of Toronto
Toronto, Ontario
Canada

Internships:

 University of Toronto
Toronto, Ontario
Canada
1985

Residency:

 University of Toronto
Toronto, Ontario
Canada
1987

Fellowships:

 University of Calgary
Calgary, Alberta
Canada
1991

University of Western Ontario
Toronto, Ontario
Canada
1989

Board Certifications:

 American Board of Internal Medicine, Cardiovascular Medicine, 1989
American Board of Internal Medicine, 1988

Professional Memberships:

 Ad hoc member, Peer Review Committee, CVA Study Section, National Institutes of Health Member, Peer Review Committee, ESTA Study Section, National Institutes of Health
American Association for the Advancement of Science
Basic Science Council, American Heart Association
Biophysical Society
Cardiac Electrophysiology Society
Editorial Board, Circulation Research
Fellow of the American Heart Association
North American Society of Pacing and Electrophysiology
Peer Review Committee, CV Pathophysiology Study Group 1, American Heart Association, National Center
Peer Review Committee, Ohio Valley Affiliate, American Heart Association
Reviewer for Cardiovascular Research, Circulation Research, Journal of Molecular and Cellular Cardiology, American Journal of Physiology, Journal of American College of Cardiology
Society of General Physiologists
Special Emphasis Panel, ECS Study Section, National Institutes of Health

Select Recent Publications:

Nie L, Song H, Cheng M, Chiamvimonvat N, Beisel KW, Yamoah EN, Vazquez AE. Cloning and Expression of A Small Conductance Ca2+-Activated K+ Channel from The Mouse Cochlea: Coexpression with a9/a10 Acetylcholine Receptors. Journal of Neurophysiology 91: 1536-1544, 2004.

Glatter KA, Wang Q, Keating M, Chen S, Chiamvimonvat N, Scheinman MM. Effectiveness of sotalol treatment in symptomatic Brugada syndrome. American Journal of Cardiology. 93:1320-2, 2004.

Zhao Zhang, Yanfang Xu, Pei Hong Dong, Dipika Sharma, Nipavan Chiamvimonvat. A negatively charged residue in the outer mouth of rat sodium channels determine the gating kinetics of the channels. American Journal of Physiology 284: C1247-1254, 2003.

Xu Y, Tuteja D, Zhang Z, Xu D, Zhang Y, Rodriguez J, Nie L, Tuxson H, Young N, Glatter K, Vázquez AE, Yamoah E, Chiamvimonvat N. Molecular identification and functional roles of a calcium-activated K+ channel in human and mouse hearts Journal of Biological Chemistry 278:49085-49094, 2003.

Glatter KA, Chiamvimonvat N, Whitcomb C, Bloom H. Images in cardiovascular medicine. Malignant vasovagal syncope. Circulation 107:2987-8, 2003.

Xu Y, Dong PH, Ahmmed GA, Chiamvimonvat N. Functional roles of the calcium-activated chloride current in mouse ventricular myocytes. American Journal of Physiology 283: H302-H314, 2002.

Zhang Z, YF Xu, Song HT, Rodriguez J, Tuteja D, Namkung Y, Shin HS, Chiamvimonvat N. Functional roles of Cav1.3 (a1D) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circulation Research 90: 981 - 987, 2002.

Xu YF, Chiamvimonvat N, Akunuru S, Ratner N, Yamoah EN. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. Journal of Neuroscience, 22:9194-202, 2002.

Ahmmed GU, Xu YF, Dong PH, Zhang Z, Eiserich JP, Chiamvimonvat N. Nitric oxide modulates cardiac sodium channel via protein kinase A and protein kinase G. Circulation Research 89:1005-1013, 2001.

Gias AU, Dong PH, Song G, Ball NA, Xu Y, Walsh RA, Chiamvimonvat N. Changes In Ca2+ Cycling Proteins Underlie Cardiac Action Potential Prolongation In A Pressure Overloaded Guinea Pig Model With Cardiac Hypertrophy And Failure. Circulation Research, 86: 558-570, 2000.