Clinical/Research Interests

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Select Recent Publications:

Wang-Polagruto, J, AC Villablanca, L Lee, J Polagruto, RA Holt, H Schrader, J Ensunsa, FM Steinberg, H Schmitz and CL Keen. Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule (VCAM-1) in hypercholesterolemic postmenopausal women. J Cardiovascular Pharmacology. (In press)

Benton, J, A Powers, L Eiselein, R Fitch, D Wilson, AC Villablanca and JC Rutledge. Hyperglycemia and loss of ovarian hormones mediate atheroma formation through endothelial layer disruption and increased permeability. Am J Physiol. (In press)

Villablanca, AC, D Lubhan, L Shelby, K Lloyd and S Barthold. Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor a (ERa). Atherosclerosis, Thrombosis and Vascular Biology, 24:1055-1061 (with journal editorial). Erratum in: Arterioscler Thromb Vasc Biol, 24(6):1055-1061.

Nandur, R, K Kumar and AC Villablanca. Cardiovascular actions of selective estrogen receptor modulators (SERMs) and phytoestrogens. Preventive Cardiology, 7:73-79. Invited review.

Villablanca, AC, KA Lewis and JC Rutledge. Differential regulation of gene expression by ovariectomy in mouse aorta. Physiological Genomics, 12:175-185. [online] http://www.10.1152/physiolgenomics.00040.2002.

Steinberg, FM, NG Guthrie, AC Villablanca, K Kumar and MJ Murray. In healthy post-menopausal women, soy isoflavones have favorable effects on endothelial function, which are independent of lipid and antioxidant effects. Amer J Clinical Nutrition, 78:123-130.

Smith, S and AC Villablanca. The effect of estrogen on inflammatory genes and proteins in atherosclerotic vessels. UC Davis proceedings from the Howard Hughes Medical Institute Summer Honors Advanced Research Program (SHARP) Focused Integrative Research Scholar Training (FIRST).

Villablanca, AC, KA Lewis and JC Rutledge. Time- and dose-dependent differential up-regulation of three genes by 17 b-estradiol in human aortic endothelial cells. J Applied Physiology, 92(3):1064-1073. [online] November 2, 2001, http://www.10.1152/japplphysiol.00374.2001.

Ariyo, AA and Villablanca AC. Estrogens and lipids: Can HRT, designer estrogens and phytoestrogens reduce cardiovascular risk markers after menopause? Postgraduate Medicine, 111(1):23-30. Invited review.

Villablanca, AC. Hormone replacement therapy and cardiovascular risk in women: Where do we stand? Women's Health in Primary Care, 4(2):121-129. Invited review.